Scientists Find Brain Pathways for Threat Response in Mice

Scientists at the National Institute on Alcohol Abuse and Alcoholism (NIAAA) have identified brain pathways that may coordinate an animal’s response to potentially traumatic situations. Understanding where and how neural circuits mediate such functions—and how they could malfunction—may provide clues about their role in trauma-related and stress-related psychiatric disorders in people. A report of this … Read more

Semaglutide Shows Promise as a Potential Alcohol Use Disorder Medication

Intramural scientists at the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the National Institute on Drug Abuse (NIDA), and collaborators from The Scripps Research Institute, found that semaglutide reduces alcohol consumption and binge-like drinking in a rodent model of alcohol misuse. Published in the June 2023 issue of the journal JCI Insight, the study … Read more

Alcohol and Other Substance Use To Cope With Social Anxiety

Using alcohol to cope with social anxiety is associated with increased substance use and more consequences among young adults, according to a study by National Institute on Alcohol Abuse and Alcoholism (NIAAA)-supported researchers.1 The findings also suggest that young adults who drink to cope with social anxiety experience more negative consequences associated with their alcohol use, … Read more

New Research Characterizes Alcohol Use Disorder Profiles To Predict Treatment Outcomes

Alcohol use disorder (AUD) is a heterogeneous disorder, meaning individuals with AUD differ in their clinical symptoms and in the biological and psychological factors that contribute to their disorder. A better understanding of individual differences in AUD could inform the development of tailored treatment approaches to increase treatment effectiveness. New research from the University of … Read more

Researchers Gain New Insight Into the Development of Severe Alcohol-Associated Hepatitis

Alcohol misuse can lead to alcohol-associated hepatitis (AH), a form of liver disease with a high short-term mortality rate in severe cases. Currently, no medications have been approved by the U.S. Food and Drug Administration to treat AH, and liver transplantation is often required due to liver failure. A better understanding of how AH develops … Read more

NIAAA Scientists Unveil New Definition of Recovery from Alcohol Use Disorder

Scientists at the National Institute on Alcohol Abuse and Alcoholism (NIAAA) have released a new definition of recovery from alcohol use disorder (AUD) that addresses limitations associated with prior AUD recovery definitions and lays the groundwork for future recovery-related research. In a recent review article, Brett Hagman, Ph.D., Dan Falk, Ph.D., Raye Litten, Ph.D., and NIAAA Director … Read more