Reduction in Drinking Associated with Improvements in Health and Quality of Life

In clinical trials for alcohol use disorder (AUD), abstinence and no heavy drinking days are currently the only end points approved by the U.S. Food and Drug Administration. However, many individuals who do not achieve these end points may still reduce their drinking to less harmful levels during treatment. A recent study published in Alcoholism: … Read more

Improving Treatment by Measuring Neuroscience Domains

Alcohol use disorder (AUD) is a common, heterogeneous disorder, and this heterogeneity drives the need for precision treatment. In a recent study, investigators at the National Institute on Alcohol Abuse and Alcoholism (NIAAA) led by Laura E. Kwako, Ph.D., a Clinical Psychologist in NIAAA’s Office of the Clinical Director, tested the hypothesis that neurofunctional domains … Read more

A New Treatment Strategy for Alcohol-Associated Liver Disease

Alcohol is involved in nearly half of all liver disease deaths in the United States each year. Alcohol-associated liver disease (AALD) now replaces hepatitis C viral infection as the lead cause of liver transplantation due to chronic liver disease. Consequently, there is an urgent need for effective interventions for AALD, a complex disease with multiple … Read more

Prenatal Choline May Ameliorate Effects of Prenatal Alcohol Exposure

Prenatal supplements with the nutrient choline may help protect against alcohol-related deficits in children born to women who drink alcohol during pregnancy, according to a small clinical trial supported by the National Institute on Alcohol Abuse and Alcoholism (NIAAA). The new findings were reported in the July 2018 issue of Alcoholism: Clinical and Experimental Research. Choline … Read more

Mother’s Immune Profile May Influence Prenatal Alcohol Exposure Outcome

A new study has found that alcohol use during pregnancy can affect a woman’s immune system in ways that may predict her child’s neurodevelopmental outcome. Specific changes in a mother’s immune system can also serve as an indicator of prenatal alcohol use. Prenatal alcohol use can cause an array of health effects in offspring, collectively … Read more

Maternal Cytokine Balance May Play Role in FASD Risk

A study done in conjunction with the Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD), which is supported by the National Institute on Alcohol Abuse and Alcoholism, reports that disruptions in levels of certain immune system molecules during pregnancy can alter the risk for fetal alcohol spectrum disorders (FASD). The effects of alcohol consumption on the … Read more