Alcohol and “Deaths of Despair”

In 2015, Princeton University economists Anne Case, Ph.D., and Angus Deaton, Ph.D., reported something unexpected. After decreasing since the end of World War II, rates of death began to increase in the United States for people in some groups. The rise in deaths was driven primarily by drug and alcohol overdoses, suicides, and liver disease. … Read more

A New Treatment Strategy for Alcohol-Associated Liver Disease

Alcohol is involved in nearly half of all liver disease deaths in the United States each year. Alcohol-associated liver disease (AALD) now replaces hepatitis C viral infection as the lead cause of liver transplantation due to chronic liver disease. Consequently, there is an urgent need for effective interventions for AALD, a complex disease with multiple … Read more

Advancing Alcoholic Hepatitis Research

Breakthroughs in neuroscience have firmly established our understanding of alcohol use disorder (AUD) as a chronic brain disease. But when it comes to the adverse health effects of alcohol, the brain is not the only game in town. Drinking too much—on a single occasion or over time—can take a serious toll on just about every … Read more

MicroRNAs May Have Therapeutic Potential for Alcohol-Induced Liver Injury

Picture of DNA strand

MicroRNAs, or miRNAs, are short strands of RNA that play important roles in gene regulation. In two recent studies, researchers supported by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) identified two miRNAs that may help protect against alcohol-induced liver injury. Paramananda Saikia, Ph.D., and colleagues at the Cleveland Clinic, in studies conducted in … Read more