The Complex Relationship Between Alcohol and Pain

The relationship between alcohol and pain is a complicated one. It is a common belief that alcohol dulls pain, yet research shows that sometimes alcohol can make pain worse. Understanding the complex relationship between alcohol and pain is an important area of research for the National Institute on Alcohol Abuse and Alcoholism (NIAAA). In 2016, … Read more

Alcohol and “Deaths of Despair”

In 2015, Princeton University economists Anne Case, Ph.D., and Angus Deaton, Ph.D., reported something unexpected. After decreasing since the end of World War II, rates of death began to increase in the United States for people in some groups. The rise in deaths was driven primarily by drug and alcohol overdoses, suicides, and liver disease. … Read more

New preclinical study points to potential role of human gene in addiction

A new study led by researchers at the National Institute and Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health (NIH), identifies regions of the rat genome that are associated with a behavior that is highly predictive of addiction onset and progression. The region in the rat genome with the strongest association … Read more

Reduction in Drinking Associated with Improvements in Health and Quality of Life

In clinical trials for alcohol use disorder (AUD), abstinence and no heavy drinking days are currently the only end points approved by the U.S. Food and Drug Administration. However, many individuals who do not achieve these end points may still reduce their drinking to less harmful levels during treatment. A recent study published in Alcoholism: … Read more

Improving Treatment by Measuring Neuroscience Domains

Alcohol use disorder (AUD) is a common, heterogeneous disorder, and this heterogeneity drives the need for precision treatment. In a recent study, investigators at the National Institute on Alcohol Abuse and Alcoholism (NIAAA) led by Laura E. Kwako, Ph.D., a Clinical Psychologist in NIAAA’s Office of the Clinical Director, tested the hypothesis that neurofunctional domains … Read more

A New Treatment Strategy for Alcohol-Associated Liver Disease

Alcohol is involved in nearly half of all liver disease deaths in the United States each year. Alcohol-associated liver disease (AALD) now replaces hepatitis C viral infection as the lead cause of liver transplantation due to chronic liver disease. Consequently, there is an urgent need for effective interventions for AALD, a complex disease with multiple … Read more